The world of analytical chemistry is about to get a lot more exciting! We're diving into the heart of a pressing issue: the analysis of PFAS, those notorious 'forever chemicals'. But here's the catch: it's not just about any PFAS, but the tricky ultrashort and long-chain mixtures. And this is where things get really interesting...
PFAS, or per- and polyfluoroalkyl substances, are a group of chemicals with a dark side. They're used to create coatings and products that resist heat, oil, stains, and water, but they come with a toxic twist. These chemicals have raised major public health and environmental red flags, demanding our utmost attention and diligence in every step, from surveillance to production and storage.
Now, imagine you're faced with the challenge of analyzing these complex mixtures using LC-MS. It's like trying to solve a puzzle with missing pieces, and that's exactly what we'll be tackling in our upcoming webinar.
Join us on Tuesday, December 2, 2025, at 8 am PST, 11 am EST, 4 pm GMT, or 5 pm CET for a deep dive into the current LC-MS approaches for PFAS analysis. We'll explore the latest methods, including the use of superficially porous particle technology columns and the EPA's 533, 537.1, 8327, and 1633 methods. But here's where it gets controversial: we'll also discuss the recent evaluations of methods with larger injection volumes and the elimination of solid-phase extraction sample preparation. Is this the way forward, or are we sacrificing accuracy for speed?
And this is the part most people miss: the challenges of analyzing ultrashort chain PFAS like trifluoracetic acid (TFA) and PFPrA. With their low retention and sensitivity, they're a real headache for LC-MS/MS. But fear not! We'll uncover a new approach using a reversed-phase, superficially porous particle (SPP) silica with a positive charge surface chemistry and hydrophobic silane modifier (HALO® PCS). This innovative method promises to improve the analysis of short-chain PFAS while maintaining the resolution of mid- and long-chain analytes.
Our expert speaker, Conner McHale, Technical Support Specialist at Advanced Materials Technology, will guide us through these cutting-edge techniques. Don't miss out on this opportunity to stay ahead of the curve in PFAS analysis.
Register now for free at https://www.chromatographyonline.com/lcgcw/PFASanalysis and join the global community of analytical scientists who trust LCGC for the latest insights and expert solutions in chromatography.
See you there!
